Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1199 | 1199-30930 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | G73S | L10I, I15V, G16E, K20KR, E35D, M36I, R41K, K45R, R57K, Q61N, I62IV, A71V, I72R, I93L |
| >1199-30930| codons 4-99 TLWQRPIVTIKVEGQLREALLDTGADDTVLEDINLPGKWKPRMIGGIGGFVKVKQYDNVL IEICGHKVRSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V | K103N, Y181C, G190GA | S68SG, D123DE, E138EA, I142IV, T200A, I202IV, R211RK | K122K*, Y127YF |
| >1199-30930| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLD*EFRKFTAFTIPSINNATPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKVEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |