<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1114 1114-30707 Argentina 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184MV, L210W, T215Y V75I, K219E Y181C, Y188L   T39A, K43E, S48E, V90I, V106I, V118VI, I135ILM, E203D, H208Y, R211K, H221Y, E224ED, L228R E40FS
>1114-30707| codons 38-247
CASLEEEGKIEKIGPENPYNTPVFAIKKKNSDKWRKLIDFRELNKRTQDFWEIQLGIPHP
AGLKKKKSITVLDVGDAYFSIPLDKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLLVGSDLEIGQHRTKIDELRQYLWKWGFYTP
DEKYQKDPPFRWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, L90M N88D K14R, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I72T, V77VI, V82I, I93L  
>1114-30707| codons 4-99
TLWQRPLVTIRVGGQLTEALLDTGADDTVLEDIDLPGKWKPKIVGGIGGFVKVKQYDNIP
IEICGHKVTGTVLIGPTPINIIGRDLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006