Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1114 | 1114-30707 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, L90M | N88D | K14R, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I72T, V77VI, V82I, I93L |
| >1114-30707| codons 4-99 TLWQRPLVTIRVGGQLTEALLDTGADDTVLEDIDLPGKWKPKIVGGIGGFVKVKQYDNIP IEICGHKVTGTVLIGPTPINIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MV, L210W, T215Y | V75I, K219E | Y181C, Y188L | T39A, K43E, S48E, V90I, V106I, V118VI, I135ILM, E203D, H208Y, R211K, H221Y, E224ED, L228R | E40FS |
| >1114-30707| codons 38-247 CASLEEEGKIEKIGPENPYNTPVFAIKKKNSDKWRKLIDFRELNKRTQDFWEIQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLLVGSDLEIGQHRTKIDELRQYLWKWGFYTP DEKYQKDPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |