<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1053 1053-30630 Argentina 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N K101E, Y181C, G190A A98G T39S, E44D, R83K, V106I, V118I, K122E, D123E, I135T, E138EQ, G196E, Q197K, T200A, I202V, R211K  
>1053-30630| codons 38-247
CSELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHP
GGLEKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIEKHRAKVEELRQHLWKWGFYTP
DNKHQKEPPFLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, L76V, I84V L33F, L89V Q7R, L10I, I13V, G16E, K20M, N37D, A71V, I72R, I93L  
>1053-30630| codons 4-99
TLWRRPIVTVKIEGQLMEALLDTGADDTVFEEMDLPGRWKPKIVGGIGGFMKVRQYDQIL
IEICGHKVRGTVVVGPTPVNVIGRNVLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006