Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1053 | 1053-30630 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, I84V | L33F, L89V | Q7R, L10I, I13V, G16E, K20M, N37D, A71V, I72R, I93L |
| >1053-30630| codons 4-99 TLWRRPIVTVKIEGQLMEALLDTGADDTVFEEMDLPGRWKPKIVGGIGGFMKVRQYDQIL IEICGHKVRGTVVVGPTPVNVIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | A98G | T39S, E44D, R83K, V106I, V118I, K122E, D123E, I135T, E138EQ, G196E, Q197K, T200A, I202V, R211K |
| >1053-30630| codons 38-247 CSELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHP GGLEKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIEKHRAKVEELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |