Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1050 | 1050-30625 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215Y | K219Q | Y181C | T39A, E44ED, V60I, V118I, K122AP, D177E, V179VA, T200A, H208Y, R211K, F214L, D218E, L228H |
| >1050-30625| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIAICQYMDDLYVGSDLEIGQHRAKIEELRQYLLKWGLYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | V11I, Q58E, G73GS, L89V | L10I, I13V, K14R, K20I, N37N_N, R41K, K55KR, D60E, L63P, I64IV, A71I, I72M, V77I, I93L | M36E |
| >1050-30625| codons 4-99 TLWQRPIITVRIGGQLIEALLDTGADDTILEEENLPGKWKPKIVGGIGGFMRVREYEQIP VEICGHKIMSTVLIGPTPVNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |