<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1046 1046-30623 Argentina 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82S, L90M L33F, F53L L10I, T12Q, I13IV, I15V, K20R, E35D, M36I, N37ND, R41K, K55R, R57K, D60E, Q61N, I62IV, L63P, C67D, A71I, I93L  
>1046-30623| codons 4-99
TLWQRPIVQVKVGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGLVRVKQYENVP
IEIDGHKIIGTVLVGPTPSNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, L210W, T215Y K219DN K101P, G190A Y188YF E44D, V60I, V106VI, V118I, K122E, D123E, I135T, S162C, Q174K, V179I, Q207E, R211K, D218E, L228LH, I244IV  
>1046-30623| codons 38-247
CTELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLPKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKKNPDIIIYQYMDDLFVASDLEIGQHRTKIEELREHLWKWGFYTP
ENKHQKEPPFHWMGYELHPDKWTVQPVVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006