Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1046 | 1046-30623 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82S, L90M | L33F, F53L | L10I, T12Q, I13IV, I15V, K20R, E35D, M36I, N37ND, R41K, K55R, R57K, D60E, Q61N, I62IV, L63P, C67D, A71I, I93L |
| >1046-30623| codons 4-99 TLWQRPIVQVKVGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGLVRVKQYENVP IEIDGHKIIGTVLVGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219DN | K101P, G190A | Y188YF | E44D, V60I, V106VI, V118I, K122E, D123E, I135T, S162C, Q174K, V179I, Q207E, R211K, D218E, L228LH, I244IV |
| >1046-30623| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLPKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKKNPDIIIYQYMDDLFVASDLEIGQHRTKIEELREHLWKWGFYTP ENKHQKEPPFHWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |