Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1045 | 1045-30617 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | T12TK, I13IM, I15IV, K20I, E35D, M36I, R57RK, L63P, A71V, I85V, I93L | T31T_HY |
| >1045-30617| codons 4-99 TLWQRPFVKMKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVKQYDQIP IEICGHKVISTVLVGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | K103N, Y181C, G190GA | T39TAEK, V60VI, K64R, S105SA, V118I, K122E, I135T, T139R, S162SC, T165TI, D177E, E203ED, F214L, D218DE, K223Q, L228H, Q242H |
| >1045-30617| codons 38-247 CKELEKEGKISKIGPENPYNTPIFAIRKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKAVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSP AIFQCSMIKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRTKIDELRQHLLRWGLFTP EQKHQQEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |