Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1194 | 1194-30929 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54IV, I84IV, L90M | L10I, I13V, Q18H, K20T, E35D, N37PT, R41RK, Q61QHKN, I64V, I66IF, A71AV, V77VI, Q92QK |
| >1194-30929| codons 4-99 TLWQRPIVTVKIGGHLTEALLDTGADDTVLEDMTLPGKWKPKLIGGIGGFVKVRQYDNIL VEFCGHKVIGTVLIGPTPVNVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KR | Y188L | K43Q, E44D, K101Q, V118I, K122E, I178IM, G196E, H208Y, R211K, E224D, V245E |
| >1194-30929| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYMDDLLVGSDLEIEQHRTKIEELRQYLWKWGFYTP DRKHQKDPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |