Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1172 | 1172-30915 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | F53FL, G73GS | L10I, L19V, K20R, M36I, N37ND, R41K, R57RK, I62V, L63P, I64IM, A71V, I72T, I85V, I93L |
| >1172-30915| codons 4-99 TLWQRPIVTIKIGGQVREALLDTGADDTVLEEIDLPGKWKPKIIGGIGGLVKVKQYDQVP MEICGHKVTSTVLVGPTPTNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210W, T215HY | A62V | A98G | T39A, E44D, S68SG, K122E, D123N, I135T, T165I, Q174K, G196E, T200TA, I202IV, R211Q |
| >1172-30915| codons 38-247 CAELEKDGKISKIGPENPYNTPVFVIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKKNPDIVIYQYVDDLYVGSDLEIEQHRAKVEELRQHLWQWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |