Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1169 | 1169-30910 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | Y181C | V108VI | K43R, S134SG, I142V, V179I, H221Y | L193L* |
| >1169-30910| codons 38-247 CTEMEREGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSVPLDKDFRKYTAFTIPGINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVGSD*EIGQHRTKIEELRQHLLRWGFTTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47A, L90M | I15V, K20R, E35D, M36I, N37D, R41K, R57K, V77I, V82I | Q61Y |
| >1169-30910| codons 4-99 TLWQRPLVTIKVGGQLREALLDTGADDTILEDIDLPGKWKPKLAGGIGGFIKVKQYDYIL IEICGHKAIGTVLIGPTPINIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |