Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1099 | 1099-30730 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | G73S | Q7QK, L10I, I13IMV, I15V, L19LQ, K20I, M36I, N37ND, Q61N, I62V, L63P, C67F, A71V, I72L |
| >1099-30730| codons 4-99 TLWKRPIVTVKVGGQQIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYDNVP IEIFGHKVLSTVVVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | L100I, Y188L | E44D, K122E, D123T, D177E, T200E, H208Y, R211K, D218E, V245K |
| >1099-30730| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKKKSVTVLDVGDAYFSVPLDETFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLLVGSDLEIGQHREKIEELRQYLWKWGFYTP ERKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |