Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1089 | 1089-30716 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L90M | T12N, I15V, G16GE, K20RT, E35D, M36V, P39S, R41K, R57K, Q61N, I62V, L63V, A71I, I72T, V77VI, I93L |
| >1089-30716| codons 4-99 TLWQRPLVNIKVEGQLTEALLDTGADDTVLEDVNLSGKWKPKLIGGIGGFVKVKQYDNVV IEICGHKITGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101E, Y181YC, G190S | T39TA, K49R, V60I, T69TN, V90VI, D123E, I135V, V179VI, G196K, Q197K, T200I, R211K |
| >1089-30716| codons 38-247 CAEMEKEGKISRIGPENPYNTPIFAIKKKDSNKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVSSDLEIKKHRIKIEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |