Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1003 | 1003-30707 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, M184V, L210W, T215Y | K219E | E44ED, V118VI, K122E, S162D, V179I, G196E, R211K, L228LH, V245E |
| >1003-30707| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GA, I54V, V82A, I84V, L90M | L33F, Q58E, G73GS | L10I, L19I, E34Q, N37P, I62V, L63P, A71V, V77I, Q92K |
| >1003-30707| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMPLPGRWKPKMIAGIGGFVKVREYDQVP IEICGHKVISTVLIGPTPANVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |