Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1077 | 1077-30630 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | G73S | L10I, I13M, I15V, K20I, M36I, K55R, I62V, L63P, C67F, A71V |
| >1077-30630| codons 4-99 TLWQRPIVTMKVGGQLIEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVRQYDQVP IEIFGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, Q151M | F116Y, K219KQ | V90I, K122E, D177G, V179I, T200I, E203EK, H208HY, R211KT |
| >1077-30630| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPGIIIYQYMDDLYVGSDLEIGQHRIKIKELRQYLLTWGFTTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |