Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1073 | 1073-30626 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82F | L10I, I13IV, L19V, K20R, E35D, M36I, N37H, R41K, K45T, K55T, Q61D, I62IV, L63T, I64M, A71V, I72T, V77I, I93L | F53C |
| >1073-30626| codons 4-99 TLWQRPIVTVKIGGQVREALLDTGADDTVLEDIHLPGKWKPTMIGGIGGCATVRQYDDVT MEICGHKVTGTVLIGPTPFNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V, T215F | K219Q | K103N, Y181C | T39A, S48T, V118I, D123E, Q174R, D177E, H208HY, F214L |
| >1073-30626| codons 38-247 CAEMEKEGKITKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPEIVICQYVDDLYVGSDLEIGQHRTKIEELRQYLLRWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |