<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1074 1074-30626 Argentina 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82A, L90LM L24I, L33F, T74PS L10I, I13IV, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63S, E65D, A71AV, V77I, L89M, Q92QK, I93L  
>1074-30626| codons 4-99
TLWQRPIVTVKVEGQLREALIDTGADDTIFEDIDLPGKWKPKIVGGIGGFVKVKQYDNIS
IDICGHKVIGSVLIGPTPANIIGRNMMTKLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70KR, L74V K219Q Y181C, G190A   T39A, E53EQ, V106VI, D123E, I135V, A158AS, S162DG, E169D, I178L, F214L, L228N  
>1074-30626| codons 38-247
CAEMEKEGKISKIGPQNPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSITVLDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
SIFQGSMTKILDPFRKQNPDLVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP
DQKHQKEPPFNWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006