Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1074 | 1074-30626 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90LM | L24I, L33F, T74PS | L10I, I13IV, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63S, E65D, A71AV, V77I, L89M, Q92QK, I93L |
| >1074-30626| codons 4-99 TLWQRPIVTVKVEGQLREALIDTGADDTIFEDIDLPGKWKPKIVGGIGGFVKVKQYDNIS IDICGHKVIGSVLIGPTPANIIGRNMMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, L74V | K219Q | Y181C, G190A | T39A, E53EQ, V106VI, D123E, I135V, A158AS, S162DG, E169D, I178L, F214L, L228N |
| >1074-30626| codons 38-247 CAEMEKEGKISKIGPQNPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP SIFQGSMTKILDPFRKQNPDLVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP DQKHQKEPPFNWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |