Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1072 | 1072-30625 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, F53L | L10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61D, L63C |
| >1072-30625| codons 4-99 TLWQRPIVTIKVEGQLREALIDTGADDTVLEDINLPGKWIPKIIGGIGGLVRVKQYDDIC IEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, Y115F, M184V, T215Y | K219Q | G190S | T39M, D123E, I135T, E138A, R172K, D177E, I178L, V179T, D218E | K101D |
| >1072-30625| codons 38-247 CMELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLDKKKSVTVLDVGDAFFSVPLDKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPELTIYQYVDDLYVSSDLEIGQHRTKIEELRQHLLRWGFYTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |