Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1002 | 1002-30617 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50IV, I54IV, L90LM | G73GC | L10I, I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I93L |
| >1002-30617| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIGGVGGFVKVKQYDNIP IEICGHKAICTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74LV, T215F | K219Q | K103KN, Y181YC, G190GA | T39A, V60I, V90I, K122KE, I135V, D218E, L228H, V245VE |
| >1002-30617| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKVVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |