Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1066 | 1066-30617 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33I, F53L, G73GS, L89LV | L10I, I13V, K20R, E35D, M36I, R41RK, K43E, K55R, R57K, D60K, Q61N, I62V, L63P, A71I, I72E, C95L |
| >1066-30617| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVIEDINLPGKWEPKMIGGIGGLVRVKQYKNVP IEICGHKIESTVLVGPTPANIIGRNVMTQIGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, D67N, Y115F, Q151M | V75I, F77L, F116Y, K219E | K101E, Y181C, G190A | V179F | S68G, K103R, V106I, V118I, K122E, I135T, S163C, Q174R, T200TA, I202V, L210LF, F214L, L228H, V245L, L246LI |
| >1066-30617| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKNGTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLEKRKSITVLDVGDAFYSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSCMTKILEPFRKRNPDIFICQYMDDLYVASDLEIGQHRAKVEELRQHLFRWGLTTP DEKHQKEPPFHWMGYELHPDKWTVQPILIP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |