Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1063 | 1063-30612 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54IV, V82A, L90M | L33F, F53L, G73GS, N83D | L10I, I13V, I15V, K20R, M36I, R41K, Q61N, L63P, A71V, I72T |
| >1063-30612| codons 4-99 TLWQRPIVTVKVGGQLREALLDTGADDTIFEEINLPGKWKPKIIGGIGGLVKVRQYDNIP IEICGHKVTSTVLVGPTPADIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184MV, L210W, T215Y | K219R | Y188Y*FL | T39TA, E44D, V106VI, V118I, K122E, I135T, S162C, R172RK, G196GE, Q197K, H208Y, K223Q, E224D, L228R |
| >1063-30612| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFKKQNPDIVIYQYVDDLLVGSDLEIEKHRTKIEELRQYLWRWGFYTP DRKHQQDPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |