Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1064 | 1064-30611 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, V82A, L90M | V11VI, L33F, K43T, G73S | L10I, I13V, L24F, E34Q, K55R, D60E, I62V, L63P, A71V, I72K, V77I, I93L |
| >1064-30611| codons 4-99 TLWQRPIITVKIGGQLKEALFDTGADDTVFQEMNLPGRWTPKLIGGIGGFVRVRQYEQVP IEICGHKVKSTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N, Y181C | K43KQ, E44D, V60I, K64R, V118I, K122E, I135T, E138EQ, G196Q, Q197QK, T200A, I202V, Q207E, R211RK, E224DN | D110DN |
| >1064-30611| codons 38-247 CTELEQDGKISKIGPENPYNTPIFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLNVGDAYFSIPLDEDFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIQKHRAKVEELREHLWKWGFYTP DKKHQKNPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |