Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1005 | 1005-40615 | Argentina | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 53 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, M184V, L210W, T215Y | K219E, N348I | Y181C | V108I, F227L | V35M, T39S, E40F, K43E, K101Q, E138Q, G196E, H221Y, L228R, V292I, I293V, I326IV, R356K, R358RK, K390R |
| >1005-40615| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICSFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDEKYQKEPPLRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82T | L33F | L10IV, I13V, M36MI, D60E, Q61E, L63P, A71V, T74TA, V77I, L89LM, I93L |
| >1005-40615| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFEEINLPGRWKPKLIVGIGGFTKVRQYE EIPIEICGHKVIGAVLIGPTPTNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |