Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1005 | 1005-30609 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, M184V, L210W, T215Y | K219E | Y181C | V108VI, F227L | T39S, E40V, K43E, D86E, K101Q, E138EQ, G196E, H221HY, L228R | A114AG |
| >1005-30609| codons 38-247 CSVLEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQEFWEVQLGIPHP AGLQKKKSVTILDVGDGYFSVPLDKDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTP DEKYQKEPPLRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A | L33F, Q58QE | L10I, D60E, Q61E, L63P, A71V, V77I, I93L |
| >1005-30609| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFTKVREYEEIP IEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |