Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1136 | 1136-30729 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82F | L33F, K43T, N88D, L89LV | L10I, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, I85V, I93L |
| >1136-30729| codons 4-99 TLWQRPIVTIKVGGQLKEALLDTGADDTVFEDINLPGKWTPKIVGGIGGFVRVKQYDNIP IEICGHKVIGTVLVGPTPFNIVGRDVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, V75M, T215Y | K219Q | L100I, K103N | V60I, D123E, I135V, I142V, I178L, T200A, E203D, H208Y, R211K, D218E |
| >1136-30729| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKVMDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVIYQYMDDLYVGSDLEIGQHRAKIDELRQYLLKWGFYTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |