Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1084 | 1084-30714 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10V, I15V, K20R, M36I, R41K, R57K, Q61N, L63LAPV, I64L, I85IV, I93L |
| >1084-30714| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVKQYDNIV LEICGHKAIGTVLVGPTPANIVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | V179D | V60I, S68SG, V106I, D121C, K122E, I135T, I142V, D177E, L210LS, D218E |
| >1084-30714| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSVPLCEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIDIYQYVDDLYVGSDLEIGQHRTKIEELRQHLSRWGFYTP EKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |