Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1079 | 1079-30701 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, I93L |
| >1079-30701| codons 4-99 TLWQRPVVTVKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYDNIP IEICGHKVISSVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74LV, Y115F | V75VI, T215TI, K219Q | L100I, K103N | V60VI, K64KN, T69N, V90VI, K122E, I135L, Q174R, V179VI, T200TA, L228R, V245M | K46K* |
| >1079-30701| codons 38-247 CTEMEKEG*ISKIGPENPYNTPIFAINKKDSNRWRKVIDFRELNKRTQDFWEIQLGIPHP AGIKKNKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIIIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFITP DQKHQKEPPFRWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |