Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1608 | 1608-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33F, G73C | L10I, K20R, E34N, E35D, M36I, P39S, K55KR, I62V, L63P, A71T, I72IT, V77VI, I93L |
| >1608-30522| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFNDINLSGRWKPKMIGGIGGFLRVRQYDQVP IEICGHKTTCTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K219R | Y181C, G190A | A98G, V108I, F227L | E44D, K64KN, K101Q, V118I, K122E, V179I, T200TA, E203K, Q207E, H208Y, R211K, K223E, L228R, V245T |
| >1608-30522| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAINKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLQKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVASDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEEPPLRWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |