Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1607 | 1607-40518 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K103N, G190A | T27S, V35T, K49R, A98S, K122E, D123N, K166I, D177N, I195L, T200A, R211K, V245E, A272P, K277R, I293V, E297R, A355T, M357T, G359S, K366R, K390R | E29EK, K64KE |
| >1607-40518| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEKKIKALTEICTELEKEGKISRIGPENPYNTPV FAIEKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTIILEPFRKQNPNIVI YQYVDDLYVASDLELGQHRAKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYTRTRSA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84IV | L33LF | I13IV, I15V, K20R, E35D, M36I, N37D, R57K, D60E, I62V, L63P, I64V |
| >1607-40518| codons 1-99 PQITLWQRPLVTVKVGGQLREALLDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVKQYE QVPVEICGHKAIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |