Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1607 | 1607-31006 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V, T215Y | K103N, G190A | T27S, V35T, K49R, A98S, K101KQ, K122E, D123N, K166I, D177N, I195L, T200A, R211K, V245E, A272P, K277R, I293V, E297R, A355T, M357T, G359S, K366R, K390KR |
| >1607-31006| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICTELEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLQKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTIILEPFRKQNPNIVI YQYVDDLYVASDLELGQHRAKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYTRTRSA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82AT | I15V, K20R, E35D, M36I, N37D, R57K, D60E, I62V, L63P, I64V |
| >1607-31006| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVKQYE QVPVEICGHKAIGTVLVGPTPTNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |