Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3162 | 3162-30619 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53L | L10I, I15V, L19I, K20R, E35D, M36I, I62V, L63P, A71T |
| >3162-30619| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTVLEDINLPGRWKPKMIGGIGGLVKVRQYDQVP IEICGHKTIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | G190A | K101H, F227L | K43Q, E44D, V106I, V118I, K122E, S162C, D177E, T200A, E203K, Q207E, H208Y, R211K, F214L, K223E, L228R |
| >3162-30619| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIVIYQYVDDLYVASDLEIGQHRAKIKELREYLWKWGLYTP DRKHQEEPPLRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |