Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3213 | 3213-30818 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, G73T | L10IT, G16A, L24F, Q61H, I62V, L63P, I66IV, A71V, I72IL, V77I, I93L |
| >3213-30818| codons 4-99 TLWQRPTVTIKIAGQLKEALFDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYDHVP IEVCGHKVLTTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75T, T215F | K219E | L100I, Y188L | E44D, T69TN, S162SN, G196E, I202IV, E203A, D218DE, K223Q, L228H, V245K |
| >3213-30818| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSNRWRKLTDFRELNKRTQDFWEVQLGIPHP AGIKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIEQHRTKVAELRQHLLRWGFFTP EEKHQQEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |