Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3103 | 3103-30717 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184I, L210W, T215Y | K219R | Y181C, G190A | A98G, K101H, V108I | T39TK, K43E, E44A, K102Q, V118I, I135L, S162D, K166R, D177E, V189I, E203K, H208Y, R211D, K223EQ, E224ED, L228R, Q242L |
| >3103-30717| codons 38-247 CKELEEAGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLHQKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQDSMTRILEPFRKQNPEIVICQYIDDLYIASDLEIGQHRTKIKELRQYLWDWGFYTP DRKHQQDPPFRWMGYELHPDKWTVLPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, I84V | Q58E | L10I, I13V, G16E, K20M, E35D, N37T, D60E, Q61N, I62V, L63H, I64V, A71T, I72V, T91S |
| >3103-30717| codons 4-99 TLWQRPIVTVKIEGQLMEALLDTGADDTVLEDMTLPGRWKPKLIVGIGGFVKVREYENVH VEICGHKTVGTVLVGPTPANVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |