<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3103 3103-30717 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82A, I84V Q58E L10I, I13V, G16E, K20M, E35D, N37T, D60E, Q61N, I62V, L63H, I64V, A71T, I72V, T91S  
>3103-30717| codons 4-99
TLWQRPIVTVKIEGQLMEALLDTGADDTVLEDMTLPGRWKPKLIVGIGGFVKVREYENVH
VEICGHKTVGTVLVGPTPANVIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184I, L210W, T215Y K219R Y181C, G190A A98G, K101H, V108I T39TK, K43E, E44A, K102Q, V118I, I135L, S162D, K166R, D177E, V189I, E203K, H208Y, R211D, K223EQ, E224ED, L228R, Q242L  
>3103-30717| codons 38-247
CKELEEAGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
GGLHQKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP
AIFQDSMTRILEPFRKQNPEIVICQYIDDLYIASDLEIGQHRTKIKELRQYLWDWGFYTP
DRKHQQDPPFRWMGYELHPDKWTVLPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006