Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3102 | 3102-30610 | Canada | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L23I, L33F, F53L, Q58E | L10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93L |
| >3102-30610| codons 4-99 TLWQRPIVPIKVEGQVREAILDTGADDTVFEDITLPGRWKPKMIGGIGGLIKVREYDQVT IEICGKKAIGAVLVGPTPINIVGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R | T215I, K219Q | K103NS | T39E, S48T, V60I, V90I, K122E, D123S, I135T, K173T, D177E, I178L, V179VI, T200A, E204K, Q207D, R211K, L228H, V245Q |
| >3102-30610| codons 38-247 CEEMEKEGKITKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKSKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTQNPELIIYQYMDDLYVGSDLEIGQHRAKIEKLRDHLLKWGFITP DQKHQKEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |