<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3101 3101-30527 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y A62V, K219N K103N V108I, L234I K43E, E44A, V118I, K122E, N175Y, G196E, T200A, E203ED, R211K, D218E, H221HY, L228R, V245I  
>3101-30527| codons 38-247
CTELEEAGKISKIGPENPYNTPVFVIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQYPDIVIYQYVDDLYVGSDLEIEQHRAKIDELRQHLWKWGFYTP
ENKYQKEPPFRWMGYEIHPDKWTVQPIILP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L90M G73T L10I, K20I, L63P, I64V, H69R, I72M L24L*
>3101-30527| codons 4-99
TLWQRPIVTIKIGGQLIEAL*DTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP
VEICGRKAMTTVLVGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006