Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3101 | 3101-30527 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | A62V, K219N | K103N | V108I, L234I | K43E, E44A, V118I, K122E, N175Y, G196E, T200A, E203ED, R211K, D218E, H221HY, L228R, V245I |
| >3101-30527| codons 38-247 CTELEEAGKISKIGPENPYNTPVFVIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQYPDIVIYQYVDDLYVGSDLEIEQHRAKIDELRQHLWKWGFYTP ENKYQKEPPFRWMGYEIHPDKWTVQPIILP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10I, K20I, L63P, I64V, H69R, I72M | L24L* |
| >3101-30527| codons 4-99 TLWQRPIVTIKIGGQLIEAL*DTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP VEICGRKAMTTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |