Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3100 | 3100-30521 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | Y181YC | A98G | K43Q, E44D, V118I, K122E, I142V, I178IM, G196E, Q197QE, T200A, E203D, H208Y, R211K, W212M, H221HY, L228H |
| >3100-30521| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVICQYMDDLYVGSDLEIEEHRAKIDELRQYLWKMGFYTP DKKYQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L10F, L24I, K43T, I54C | L19I, K20M, E35N, M36L, N37D, L38W, K55R, R57K, D60E, I62V, L63P, I64V, A71V, I93L |
| >3100-30521| codons 4-99 TLWQRPFVTIKIGGQIMEALIDTGADDTVLENLDWPGRWTPKIIGGIGGFCRVKQYEQVP VEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |