Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3098 | 3098-30512 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11IL, Q58E, G73S, L89V | I13V, I15V, L19LI, K20I, E35D, M36I, N37NS, R41K, K55KR, R57RK, D60DEKN, I62V, L63P, A71T, I72L |
| >3098-30512| codons 4-99 TLWQRPFLTVKVGGQIIEALLDTGADDTVLEDISLPGKWKPKIIGGIGGFVRVKEYNQVP IEICGHKTLSTVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | K219Q | K43EQ, E44D, I94L, A98S, V118I, K122E, I135V, V179I, G196E, E203K, Q207D, H208Y, L210Y, R211K, D218E, L228H, Q242H |
| >3098-30512| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHP SGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRTKIKELRDYLYKWGFYTP EQKHQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |