Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3196 | 3196-30617 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, L210W, T215Y | K219E | G190Q | K43Q, K64R, V118I, K122E, S162D, V179I, T200A, R211RK, D218E, L228H, V245M | V148VE |
| >3196-30617| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIRKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNELPQGWKGSP AIFQDSMTKILEPFRKQNPDIIIYQYVDDLYVQSDLEIGQHRAKIEELRQHLWKWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I50V, I54S, V82A | L33F | L10V, L19LI, E34Q, R41K, I62V, L63P, A71V, T74S, V77I, I93L |
| >3196-30617| codons 4-99 TLWQRPVVTIKIGGQIKEALLDTGADDTVFQEMNLPGKWKPKLIVGVGGFSKVRQYDQVP IEICGHKVIGSVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |