Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3195 | 3195-30523 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GA, I54V, V82S | L10F, Q58E | K20R, E35D, M36I, N37D, D60E, Q61QK, L63P, A71V |
| >3195-30523| codons 4-99 TLWQRPFVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIAGIGGFVKVREYEKIP IEICGHKVIGTVLVGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | G190A | K101H | K43Q, E44D, V118I, E203K, Q207D, R211K, L228Q |
| >3195-30523| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIGQHRTKIKELRDHLWKWGFYTP DKKHQKEPPFQWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |