<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3051 3051-30512 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, V75M, Q151M, M184V, T215F F77L, F116Y, K219Q L100I, K103N V108I T39TAEK, V111I, K122E, G196E, E203K, Q207E, F214L, D218E, L228H, V245K  
>3051-30512| codons 38-247
CKELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLMDLRELNKRTQDFWEVQLGIPHP
AGIKKNKSVTILDIGDAYYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELREHLLRWGLFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54S, V82A L24I, L33F, Q58E L10I, I13V, D60E, L63P, V77I, L89LM  
>3051-30512| codons 4-99
TLWQRPIVTVKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIVGIGGFSKVREYEQIP
IEICGHKAIGTVLIGPTPANIIGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006