Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3051 | 3051-30512 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L24I, L33F, Q58E | L10I, I13V, D60E, L63P, V77I, L89LM |
| >3051-30512| codons 4-99 TLWQRPIVTVKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIVGIGGFSKVREYEQIP IEICGHKAIGTVLIGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, Q151M, M184V, T215F | F77L, F116Y, K219Q | L100I, K103N | V108I | T39TAEK, V111I, K122E, G196E, E203K, Q207E, F214L, D218E, L228H, V245K |
| >3051-30512| codons 38-247 CKELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLMDLRELNKRTQDFWEVQLGIPHP AGIKKNKSVTILDIGDAYYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELREHLLRWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |