Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3029 | 3029-40406 | Canada | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | L10F, G73ST | L19IV, K20R, E35ED, M36MI, R41K, K55R, I62V, L63P, A71I, I72LV, V77VI, I85V, I93L |
| >3029-40406| codons 4-99 TLWQRPFVTIKIGGQVREALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVRVRQYDQVP IEICGHKIVTTVLIGPTPTNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N | T39N, K43Q, E44D, V60I, V118I, K122E, D123DE, I135V, S162Y, D177N, G196E, R211K, L228Q |
| >3029-40406| codons 38-247 CNELEQDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFQWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |