Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3029 | 3029-30312 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | G73S | L10I, L19V, R41K, K55KR, I62IV, L63P, A71I, I72V, V77I, I85V, I93L |
| >3029-30312| codons 4-99 TLWQRPIVTIKIGGQVKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYDQVP IEICGHKIVSTVLIGPTPTNIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N | T39N, K43Q, E44D, V60I, K102KQ, V118I, K122E, D123DE, I135V, S162Y, D177N, I178IM, G196E, R211K, L228Q |
| >3029-30312| codons 38-247 CNELEQDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPNMVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFQWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |