Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3046 | 3046-30312 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | Y188L | A98G | K43N, E44D, V106I, V118I, K122E, D123E, T139A, I142V, S162Y, T200TA, E203K, Q207E, H208Y, R211K, K223E, L228Q |
| >3046-30312| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSINNEAPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEEPPFQWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, V11I, G73S | I15V, L19P, K20I, A22V, E35D, M36I, I62V, L63P, A71V, I72L, N83NS, I85V |
| >3046-30312| codons 4-99 TLWQRPFITIKVGGQPIEVLLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |