<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3046 3046-30312 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M L10F, V11I, G73S I15V, L19P, K20I, A22V, E35D, M36I, I62V, L63P, A71V, I72L, N83NS, I85V  
>3046-30312| codons 4-99
TLWQRPFITIKVGGQPIEVLLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYDQVP
IEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R Y188L A98G K43N, E44D, V106I, V118I, K122E, D123E, T139A, I142V, S162Y, T200TA, E203K, Q207E, H208Y, R211K, K223E, L228Q  
>3046-30312| codons 38-247
CTELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
GGLKKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSINNEAPGVRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRAKIKELREYLWKWGFYTP
DRKHQEEPPFQWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006