Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3028 | 3028-30311 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75T, M184V, T215Y | A62V, K219N | G190T | A98G | K43KE, E44EA, K122E, I135T, Q197EK, E203K, Q207E, H208Y, W212L, K223Q, L228H, V245Q |
| >3028-30311| codons 38-247 CTELEEAGKISKIGPENPYNTPVFVIKKKDSTKWRKVTDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVTSDLEIGKHRTKIKELREYLLRLGFYTP DNKHQQEPPFHWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L33F, G73S | L10I, L24*, E34Q, R41K, K55R, D60E, I62V, L63P, I66L, K70R, A71V, V77I |
| >3028-30311| codons 4-99 TLWQRPIVTIKIGGQLKEAL*DTGADDTIFQEMNLPGKWKPKIVGGIGGFMRVRQYEQVP IELCGHRVISTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |