Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3027 | 3027-30310 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, L210W, T215Y | K219H | Y181C | T39E, E40F, K43E, K101Q, V118I, K122E, V179I, G196E, T200TI, E203D, H208Y, R211K, D218E, K223Q, L228H, Q242H |
| >3027-30310| codons 38-247 CEFLEEEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVGSDLEIEQHRIKIDELRQYLWKWGFYTP EHKHQQEPPFHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73S | L10I, I15V, L19LQ, K20I, E35D, M36I, N37E, R57K, D60DE, I62V, L63P, H69Q, A71I, Q92K, I93M |
| >3027-30310| codons 4-99 TLWQRPIVTIKVGGQQIEALLDTGADDTVLEDIELPGRWKPKMIGGIGGFVKVKQYEQVP IEICGQKIISTVLVGPTPVNVIGRNLMTKMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |