Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3024 | 3024-30306 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L33F, T74P | L10I, V11L, I13V, N37D, R41K, I62V, L63P, A71V, I72V, V77VI, I93L |
| >3024-30306| codons 4-99 TLWQRPILTVKIGGQLKEALLDTGADDTVFEEMDLPGKWKPKIIGGIGGFVKVRQYDQVP IEICGHKVVGPVLIGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | Y181YC | V108VI | K43Q, E44D, V118I, K122E, D177E, I178IM, G196E, E203K, Q207E, R211K, D218DE, K223KQ, L228LH |
| >3024-30306| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVICQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTP ENKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |