Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3022 | 3022-30304 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219KR | K101E, Y181C, G190A | V108I | T39E, E44D, K103R, V118I, K122E, I135T, S162SN, V189I, Q207E, D218DE, V245K |
| >3022-30304| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIGQHRTKIEELREHLWRWGFYTP ERKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V, L90M | V11VI, L33F, G73A, L89V | L10I, I13V, G16A, E34EQ, N37D, K55KR, L63P, I72M, V77I, I93L |
| >3022-30304| codons 4-99 TLWQRPIITVKIAGQLKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGFLRVRQYDQIP IEICGHKAMATVVIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |