<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3022 3022-30304 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y K219KR K101E, Y181C, G190A V108I T39E, E44D, K103R, V118I, K122E, I135T, S162SN, V189I, Q207E, D218DE, V245K  
>3022-30304| codons 38-247
CEELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLEKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQNSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIGQHRTKIEELREHLWRWGFYTP
ERKHQKEPPFLWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, I84V, L90M V11VI, L33F, G73A, L89V L10I, I13V, G16A, E34EQ, N37D, K55KR, L63P, I72M, V77I, I93L  
>3022-30304| codons 4-99
TLWQRPIITVKIAGQLKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGFLRVRQYDQIP
IEICGHKAMATVVIGPTPVNVIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006